Toxicity, Diabetes, and Your Liver

Toxicity, Diabetes, and Your Liver

Toxicity, Diabetes, and Your Liver


Topics Covered:

Living in a Toxic World
Insulin-Resistance, Metabolic Syndrome, and Diabetes
A Functional and Integrative Model: Health Begins with Proper Liver Function
The Role of Fat
Conditions Associated with Liver Damage
Dr. Wangs Ketsumeisei™
Proven Benefits* with Ketsumeisei™
Appendix A: Excerpts from Dr. Xianen Wang, MD, PhD
A Closer Look into Type 2 Diabetes


“The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom.” -Isaac Asimov⁺

Living in a Toxic World

In the last 40-50 years (my lifetime and most likely yours), we have seen an unprecedented explosion in the manufacture and wide-spread use of chemicals, plastics, and food additives that are toxic to the human body.  The documentary “Our Chemical Lives” focuses on the myriad of chemicals in our air, food, water, and household products.  Every year, research continues to uncover detrimental health consequences due to chemical toxicity.

84,000 chemicals are legal for commerce in the U.S. and the use of each is essentially unregulated. In 2011, chemical production generated more than $763 billion in revenue.  For example, the six billion pounds of BPA (Bisphenol A) produced every year yields nearly $8 billion in profits for its manufacturers.

Common household chemicals, plastics, pesticides/herbicides, and industrial pollutants affect the neurological and endocrine systems of the human body.  They are often referred to as “endocrine disruptors” and “neuro-toxins” because of their ability to alter the normal function of hormones – both metabolic and reproductive – and neurotransmitters.  Endocrine glands regulate vital physiological processes such as blood sugar regulation, metabolism, reproduction, and growth and development.

In 2005, the Environmental Working Group (EWG) conducted a landmark study1 to investigate our exposure to environmental toxins.  EWG found an average of 200 industrial chemicals and pollutants in the umbilical cord blood of infants born in the U.S.

Laboratory testing detected a total of 287 chemicals from pesticides, consumer products, food packaging and environmental waste which included BPA, flame-retardants, PCBs, and even DDT. EWG reported:

“Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests. The dangers of pre- or post-natal exposure to this complex mixture of carcinogens, developmental toxins, and neurotoxins have never been studied.”

Insulin-Resistance, Metabolic Syndrome, and Diabetes

In the same time frame discussed regarding the chemical industry, the prevalence of chronic disease has also sky-rocketed. In particular, the prevalence of insulin-resistance/metabolic syndrome, rates of diabetes, and the number of new cases of diabetes each year are staggering. This is alarming to both individuals and their families, as well as our struggling healthcare system. Consider these statistics from the American Diabetes Association2:


  • Prevalence: In 2012, 29.1 million Americans, or 9.3% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes.
  • Undiagnosed: Of the 29.1 million, 21.0 million were diagnosed, and 8.1 million were undiagnosed.
  • Prevalence in Seniors: The percentage of Americans age 65 and older affected by the disease remains high, at 25.9%, or 11.8 million seniors (diagnosed and undiagnosed).
  • New Cases: 1.4 million Americans are diagnosed with diabetes every year.
  • Prediabetes: In 2012, 86 million Americans age 20 and older had prediabetes; this is up from 79 million in 2010.
  • Deaths: Diabetes remains the 7th leading cause of death in the United States in 2010, with 69,071 death certificates listing it as the underlying cause of death, and a total of 234,051 death certificates listing diabetes as an underlying or contributing cause of death.

Reversible disorders characterized by high blood sugar levels (hyperglycemia) have been historically treated in the western industrialized world by using pharmaceuticals. These drugs are generally considered “inhibitors” as they affect the body by inhibiting either glucose absorption in the blood or by limiting gluconeogenesis (the production of glucose) in the liver. The development of insulin and other medications to improve blood sugar regulation have failed to lower the incidence of diabetes.  Although these drug products do help to decrease glucose levels in some people, they do not address the “root cause” of the hyperglycemic problem and many have significant side effects.
The following is a list of typical and concerning complications or co-morbid conditions3 related to diabetes and blood sugar metabolism dysfunction:

  • Hypoglycemia: In 2011, about 282,000 emergency room visits for adults aged 18 years or older had hypoglycemia as the first-listed diagnosis and diabetes as another diagnosis.
  • Hypertension: In 2009–2012, of adults aged 18 years or older with diagnosed diabetes, 71% had blood pressure greater than or equal to 140/90 millimeters of mercury or used prescription medications to lower high blood pressure.
  • Dyslipidemia: In 2009–2012, of adults aged 18 years or older with diagnosed diabetes, 65% had blood LDL cholesterol greater than or equal to 100 mg/dl or used cholesterol-lowering medications.
  • CVD Death Rates: In 2003–2006, after adjusting for population age differences, cardiovascular disease death rates were about 1.7 times higher among adults aged 18 years or older with diagnosed diabetes than among adults without diagnosed diabetes.
  • Heart Attack Rates: In 2010, after adjusting for population age differences, hospitalization rates for heart attack were 1.8 times higher among adults aged 20 years or older with diagnosed diabetes than among adults without diagnosed diabetes.
  • Stroke: In 2010, after adjusting for population age differences, hospitalization rates for stroke were 1.5 times higher among adults with diagnosed diabetes aged 20 years or older compared to those without diagnosed diabetes.
  • Blindness and Eye Problems: In 2005–2008, of adults with diabetes aged 40 years or older, 4.2 million (28.5%) people had diabetic retinopathy (damage to the small blood vessels in the retina that may result in loss of vision).
  • Kidney Disease: Diabetes was listed as the primary cause of kidney failure in 44% of all new cases in 2011.

-In 2011, 49,677 people of all ages began treatment for kidney failure due to diabetes.

-In 2011, a total of 228,924 people of all ages with kidney failure due to diabetes were living on chronic dialysis or with a kidney transplant.

  • Amputations: In 2010, about 73,000 non-traumatic lower-limb amputations were performed in adults aged 20 years or older with diagnosed diabetes. About 60% of non-traumatic lower-limb amputations among people aged 20 years or older occur in people with diagnosed diabetes.

A Functional and Integrative Model:
Health Begins with Proper Liver Function

If diabetes is a blood sugar regulation problem, why are so many of its complications related to circulatory dysfunction? The mainstream medical community’s understanding of the integrative nature of the body is slowly catching up with the philosophies more commonly found in alternative/complementary medicine and traditional ancestral health practices.

These models may already recognize that hyperglycemia is a symptom of diabetes, not its cause.  They recognize that diabetes is more likely a disease of the liver than of the pancreas and that the root causes of diabetes are found in metabolic and circulatory impairments.

With this understanding, the connection between a toxic environment/body and the function of the liver is glaringly apparent. Today, we are continuously exposed to more toxins than we were designed to dispose of and of types never imagined.  As numerous and copious environmental toxins enter our bloodstream, the liver is tasked with detoxifying our cells by breaking down these substances and expelling them from the body.

At the same time, the liver must manage its major and daily functions that include:

  • Bile production and excretion
  • Excretion of bilirubin, cholesterol, hormones, and drugs
  • Metabolism of fats, proteins, and carbohydrates
  • Enzyme activation
  • Storage of glycogen, vitamins, and minerals
  • Synthesis of plasma proteins, such as albumin, and clotting factors
  • Blood detoxification and purification

The liver is constantly juggling the demands generated from its usual “to-do” list with a daily influx of toxicity from the foods we eat, the water we drink, the air we breathe, and the products we use.  The liver is perhaps the body’s most over-worked organ and most susceptible to injury.  The modern western lifestyle continually adds insult to injury.

An array of factors can damage the liver – a diet low in nutrients and high in fat and calories, an unhealthy lifestyle, smoking and alcohol use, lack of exercise, and toxins.  Over the past century, changes in the food supply, the increase in environmental toxin exposure, the overuse of pharmaceutical drugs, and a high-stress lifestyle have drastically increased the load placed on the liver.

The liver struggles to keep up; it must physically break down and expel an overwhelming number of toxins on their first pass through the bloodstream.  This chronic scenario can lead to liver damage and affect the liver’s ability to maintain its normal functions related to energy metabolism and detoxification.

The Role of Fat

In addition to toxins circulating in the blood that demand attention from the liver, free fatty acids (fat circulating in the bloodstream not packaged into triglycerides) contribute to inflammation, toxic fat breakdown products, and oxidative stress.  The constant and persistent presence of fat in the bloodstream interferes with the insulin receptor pathway and leads to insulin resistance in our muscles, a precursor to prediabetes and type 2 diabetes.  As the level of fat in the blood rises, the body’s ability to clear glucose from the blood is dramatically reduced.4  Two detrimental conditions arise – the need for more insulin to be generated and a shortage of energy being transported to our cells.

A similar feedback loop exists within the liver itself.  The brain requires a steady supply of energy to function.  While we sleep, we are also fasting in a physiological sense.  The liver can synthesize glucose (gluconeogenesis) or send stored glucose to the brain as needed during this time.  Insulin normally tells the liver to stop producing unwanted glucose.  Excess fat in the liver blocks these processes which can lead to excessive glucose production.  People with blood sugar regulation issues tend to have far more gluconeogenesis.  High insulin levels, therefore, can be a cause or a result of insulin resistance.

The co-morbidity of obesity with the diagnosis of diabetes is then of no surprise.  The number of fat cells in the human body remains constant in adulthood.  Even after significant weight loss, fat cells shrink as they offload stored fat, but the number stays the same.  Conversely, when we gain weight, fat cells stretch to accommodate the amount being pushed into each individual fat cell.  At a certain point, the fat cells become so bloated that they spill fat back into the bloodstream.

This is called the spillover effect.  Not only does an obese person have more fat, but they’re constantly spilling that fat into their bloodstream.  This fat can become lodged in our muscle cells leading to localized insulin resistance at the site.  Because fat cells are also used to store toxic substances to prevent them from circulating in the body, a release of those stored toxins may also occur with the spillover of fat into the bloodstream.  Another burden on the liver is born.

Conditions Associated with Liver Damage

Given the complex and integrated processes related to blood sugar metabolism, we see several conditions associated with the underlying condition of a congested liver. If the root causality of insulin resistance, prediabetes, and diabetes are addressed, we can expect improvement in conditions also associated with liver damage.

Conditions Associated with Liver Damage:

  • Metabolic Syndrome
  • Microcirculatory Disturbances
  • Type 2 Diabetes
  • Cardiovascular Disease
  • Neuropathy
  • Erectile Dysfunction
  • Cellular Damage
  • Lack of Energy
  • Excessive Salty/Sweet Cravings
  • Arterial Occlusion
  • Mood Disorders
  • Concentration Difficulties
  • Cerebral Infarction
  • Myocardial Infarction

Dr. Wang’s Ketsumeisei™

Dr. Xianen Wang, trained in both allopathic and Traditional Chinese Medicine, initially created the Ketsumeisei™ blend to combat type 2 diabetes.*  After noticing an increasing number of patients suffering and dying from complications of diabetes, Dr. Wang began researching viable diabetes treatments.  He realized the development of insulin and other medications did not lower the incidence of diabetes; they simply provided local treatment for certain symptoms.  To address the underlying factors that contribute to hyperglycemia and other complications of diabetes, Dr. Wang formulated Ketsumeisei™ – a revolutionary proprietary blend of Chinese herbs that support the entire body by improving metabolic and microcirculatory function.*

Ketsumeisei™ is relatively new to the U.S. but it has been a popular product in China and Japan for many years.  It is a proprietary blend of Chinese herbs which studies have shown to be effective in supporting healthy metabolic and microcirculatory functions in the body. By improving liver function and microcirculation, Ketsumeisei™ may help normalize blood sugar levels while also improving secondary conditions related to diabetes.*

When compared to the inhibiting action of diabetic pharmaceuticals, Ketsumeisei™ may be best described as a “facilitator.”  Rather than diminish a particular function involved in symptomology, this powerful formula improves microcirculation throughout the body which in turn has widespread beneficial effects on all organs, including the liver.*

Persons suffering from reversible disorders characterized by hyperglycemia generally benefit from improved liver function.  Most have developed their condition over a period of time, often as a result of poor nutrition, unhealthy lifestyle, and lack of regular exercise.

Reversing the effects of an over-burdened liver takes time.  Ketsumeisei™ can be an effective tool in this quest due to the beneficial impact on microcirculation and liver health.*

Proven Benefits* with Ketsumeisei™:

*Microcirculation improvements
*Increased energy levels
*Blood cleansing properties
*Extremity circulation improvements
*Sexual health benefits
*Improved visual acuity
*Improved liver function
*Normalized blood sugar levels
*General organ well-being

Conditions Improved*:

*Poor liver function
*Metabolic syndrome
*Type 2 diabetes
*Microcirculatory disturbances
*Cardiovascular issues
*Lack of energy
*Excess free fats in blood
*Excessive salty/sweet cravings
*Arterial occlusion
*Mental health
*Cell damage
*Brain fog
*Cerebral Infarction
*Myocardial infarction
*Erectile dysfunction



At World Nutrition Inc., we adhere to the philosophy of employing natural approaches to health and healing.  Each one of our products is comprised of a proprietary blend of vegetarian ingredients** formulated for optimum absorption and benefit.  Free of toxins, allergens, and side effects, our nutraceuticals are manufactured with the highest purity and quality standards.

We believe that the best approach to vibrant health combines western and eastern medicine.  Our philosophy is simple:  we focus on identifying problems at their source.  Current conventional medicine revolves around controlling and minimizing symptoms but gives little credence to restoring systemic function.  Our goal is to improve your health by addressing the root cause and reestablishing health and balance with superior systemic enzyme supplements.

Licensed practitioners are eligible to receive 50% off their first order to test Ketsumeisei™ for personal use. To speak with a dedicated account manager about wholesale accounts, please call us at 800.548.2710 or visit Ketsumeisei™ for product information and ordering.

Appendix A: Excerpts from Dr. Xianen Wang, MD, PhD
A Closer Look into Type 2 Diabetes

What is the root cause of type 2 diabetes?
The root cause of type 2 diabetes is cell dysfunction in terms of catabolism.  This will happen by lifestyle, medical conditions or genetics.

What is catabolism?
Catabolism is the set of pathways that break down molecules into smaller units and release energy.

What does it mean to have excess presence of glucose in the blood?
It simply indicates a result of insufficient release of energy by the cell itself and is by no means a cause of type 2 diabetes. And, this process (catabolism) is influenced by the liver. With this said, what needs to be done is to reactivate catabolism by improving liver function.

What is the modern misconception about treatment of cardiovascular issues?
Cardiovascular issues such as myocardial infarction, cerebral infarction, and arterial occlusion are often associated with metabolism obstacle thrombosis. Without knowing the root cause of the thrombosis, the medical industry often tries to prevent or remove the thrombi as a way to treat cardiovascular issues.

How does thrombi actually occur?
Thrombi occurs by activated platelet when the blood vessels are damaged (hemostasis). No thrombus forms when the vascular functions return to normal. Once liver functions slow with depression of detoxification ability, inflammation factors diffuse vascular damage, form thrombi one after another, and cause atheroma with inflammation. It is important to improve liver functions rather than covering up the symptoms.

Diabetes Epidemic
Our modern lifestyle has resulted in a sharp increase in type 2 diabetes, which is now a major problem for society.  Diabetes is a disease involving insulin, a hormone necessary to convert sugar, starches, and other carbohydrates into energy needed for daily life. In type 1 diabetes, the body does not produce insulin. In the more common type 2 diabetes, the body produces too little insulin or “resists” the hormone by failing to use it properly.Type 2 diabetes results from genetic factors along with stress, poor diet, obesity, lack of exercise, and other lifestyle habits. It is a metabolic and circulatory disorder that without proper treatment may lead to kidney, nerve, and eye damage as well as heart attack and other complications.

Treatment has always included lowering and controlling the patient’s blood sugar levels. Because even effective blood sugar control often fails to stop further complications, treatment now includes improving their symptoms to prevent more damage. Current treatments for complications are inadequate and may cause serious side effects, especially when the patient is taking several drugs. Ketsumeisei™ cannot be taken by patients with a history of hypersensitivity to any of its components.  To date, the compound has caused no known interactions with other drugs.  Patients who are pregnant or nursing should consult a healthcare practitioner before using Ketsumeisei™.  Like any other compound, it should be kept out of reach of children.

How long must a patient take Ketsumeisei™ in order to see results?
Although many patients see some results in one month, the average trial is two months.

Does Ketsumeisei™ affect the following common diabetes complications:  heart disease and stroke; kidney disease; eye, foot, or skin complications; nerve damage; digestive disturbances; depression?
The common causes for diabetes complications are metabolic and microcirculatory failures.  Because of its benefits throughout the body, Ketsumeisei™ can be taken for these complications.*

How much Ketsumeisei™ does the body absorb?

If Ketsumeisei™ is taken on an empty stomach, more than 90% is absorbed.

What are the known side effects of Ketsumeisei™ in type 2 diabetes patients?
None at present.

Is there a particular diet that works most efficiently when taking Ketsumeisei™?
Patients need to follow a healthy diet, limit alcohol intake, and engage in regular physical exercise.

Sources Cited:
1 EWG July 14, 2005
4 News Physiol Sci. 2004 Jun;19:92-6. How free fatty acids inhibit glucose utilization in human skeletal muscle. Roden M.
+ American author and biochemist (January 2, 1920-April 6, 1992)
** Flexera, our proprietary formula for joint health, does contain chondroitin sourced from shellfish.



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